Swimming training affects apoptosis-related microRNAs and reduces cardiac apoptosis in mice
نویسندگان
چکیده
منابع مشابه
Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene expression in almost all biological events. In the past decade, the involvement of miRNAs in various cardiovascular disorders has been explored in numerous in vitro and in vivo studies. In this paper, studies focused upon the discovery of miRNAs, their target genes, and functionality are reviewed. The select...
متن کاملMicroRNAs and Apoptosis
MicroRNAs (miRNAs) are small non-coding RNAs of 19-25 nucleotides that post-transcriptionally regulate the expression of target mRNA transcripts. They have been found involved in different processes commonly altered during tumorigenesis such as proliferation, differentiation and apoptosis. Here we will overview the last insights about microRNAs and apoptosis with the focus on two related miRs, ...
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The objective of this work was to test the hypothesis that endurance training may be protective against in vivo doxorubicin (DOX)-induced cardiomyopathy through mitochondria-mediated mechanisms. Forty adult (6-8 wk old) male Wistar rats were randomly divided into four groups (n = 10/group): nontrained, nontrained + DOX treatment (20 mg/kg), trained (14 wk of endurance treadmill running, 60-90 m...
متن کاملExercise training attenuates diabetes-induced cardiac injury through increasing miR-133a and improving pro-apoptosis/anti-apoptosis balance in ovariectomized rats
Objective(s): The useful and effective role of exercise program to prevent cardiac tissue apoptosis and fibrosis in ovariectomized type 2 diabetic (T2DM) rats (OVR.D) is well known. The current study aimed to investigate the simultaneous effects of T2DM and swimming plan on the expression of some apoptotic, anti-apoptotic biomarkers and glycogen changes in the cardiac ...
متن کاملDuration-controlled swimming exercise training induces cardiac hypertrophy in mice.
Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workloa...
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ژورنال
عنوان ژورنال: General physiology and biophysics
سال: 2016
ISSN: 1338-4325
DOI: 10.4149/gpb_2016012